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Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP (2018) Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimers disease
While GTs initiate extracellular GSH breakdown, the primary intracellular degradation pathway is now thought to be mediated by the cationic transport regulator homolog (ChaC)-like family of -glutamylcyclotransferases (GCT) ( ChaC-like family proteins are remarkably conserved, being found across all phyla from bacteria to humans, where they catalyze intracellular GSH degradation and yield 5-oxoproline and cysteinylglycine (Figure 2)
Sugars and plant innate immunity
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